Cloned (Comment) | Organism |
---|---|
gene CYP7A1, genotyping, overview. Expression of promoter constructs in HepG2 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | naturally occuring promoter variant -204A > C (rs3808607) of the CYP7A1 gene, genotyping, functionality of the -204A > C variant, electrophoretic mobility gel shift assays, overview. The C-construct causes a 78% promoter activity increase and gel-shift assays howed lower affinity for nuclear transcription factors, while in silico experiments predict a binding site for inhibitory nuclear factors RXR-CAR | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene CYP7A1 | - |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7alpha-hydroxylase | - |
Homo sapiens |
CYP7A1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | CYP7A1 is an enzyme involved in bile acid synthesis | Homo sapiens |
additional information | lipid responses of 67 subjects of different promoter variants -204A > C, 31 AA and 36 AC+ CC, to plant sterols, overview. Compared to AA-subjects, C-carriers show significantly higher adjusted mean reductions in total cholesterol and increases in lathosterol-to-cholesterol ratios | Homo sapiens |